All times are EST so adjust accordingly. Enjoy your day.
| First Round — Saturday, March 20 | |||
| (5) Colorado vs. (12) Georgetown | 12:15 p.m. | CBS | Hinkle Fieldhouse |
| (4) Florida State vs. (13) UNC Greensboro | 12:45 p.m. | truTV | Bankers Life Fieldhouse |
| (3) Kansas vs. (14) Eastern Washington | 1:15 p.m. | TBS | Indiana Farmers Coliseum |
| (8) LSU vs. (9) St. Bonaventure | 1:45 p.m. | TNT | Simon Skjodt Assembly Hall |
| (1) Michigan vs. (16) Texas Southern | 3 p.m. | CBS | Mackey Arena |
| (5) Creighton vs. (12) UC Santa Barbara | 3:30 p.m. | truTV | Lucas Oil Stadium Unity (South) |
| (2) Alabama vs. (15) Iona | 4 p.m. | TBS | Hinkle Fieldhouse |
| (6) USC vs. (11) Drake | 4:30 p.m. | TNT | Bankers Life Fieldhouse |
| (2) Iowa vs. (15) Grand Canyon | 6:25 p.m. | TBS | Indiana Farmers Coliseum |
| (7) UConn vs. (10) Maryland | 7:10 p.m. | CBS | Mackey Arena |
| (4) Virginia vs. (13) Ohio | 7:15 p.m. | truTV | Simon Skjodt Assembly Hall |
| (8) Oklahoma vs. (9) Missouri | 7:25 p.m. | TNT | Lucas Oil Stadium Equality (North) |
| (1) Gonzaga vs. (16) Norfolk State | 9:20 p.m. | TBS | Bankers Life Fieldhouse |
| (6) BYU vs. (11) UCLA | 9:40 p.m. | CBS | Hinkle Fieldhouse |
| (3) Texas vs. (14) Abilene Christian | 9:50 p.m. | truTV | Lucas Oil Stadium Unity (South) |
| (7) Oregon vs. (10) VCU | 9:57 p.m. | TNT | Indiana Farmers Coliseum |