| MTSU at Charlotte | 5:30 pm | CBSSN / CBS Video |
| Brown at Harvard | 6:00 pm | ESPNU / ESPN Video |
| Wake Forest at Virginia | 6:00 pm | ESPN2 / ESPN Video |
| Liberty at Syracuse | 7:00 pm | ACC Network / ESPN Video |
| UNLV at Fresno State | 9:00 pm | CBSSN / CBS Video |
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College Football Open Thread | 2021.09.24
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