All games are on Eastern Standard Time. There’s an important one in the 5 o’clock hour.
| Second Round — Sunday, March 21 | |||
| (1) Illinois vs. (8) Loyola Chicago | 12:10 p.m. | CBS | Bankers Life Fieldhouse |
| (1) Baylor vs. (9) Wisconsin | 2:40 p.m. | CBS | Hinkle Fieldhouse |
| (3) West Virginia vs. (11) Syracuse | 5:15 p.m. | CBS | Bankers Life Fieldhouse |
| (3) Arkansas vs. (6) Texas Tech | 6:10 p.m. | TNT | Hinkle Fieldhouse |
| (2) Houston vs. (10) Rutgers | 7:10 p.m. | TBS | Lucas Oil Stadium Unity (South) |
| (7) Florida vs. (15) Oral Roberts | 7:45 p.m. | truTV | Indiana Farmers Coliseum |
| (5) Villanova vs. (13) North Texas | 8:45 p.m. | TNT | Bankers Life Fieldhouse |
| (4) Oklahoma State vs. (12) Oregon State | 9:40 p.m. | TBS | Hinkle Fieldhouse |